A Digital Realization of Neuroglial Interaction Model and Its Network Structure

Astrocyte cells, the most existing abundant cells in central nervous system, play an essential role modulating neuronal activities, information processing, and regulating synaptic plasticity through calcium (Ca2+) fluctuations of ions hemostasis by using a feedback mechanism. The pathophysiological hypersynchronous activity can lead to epileptic seizures, which is known as one neurodegenerative disorders field neuroscience. This paper presents modified neuron-astrocyte interaction (tripartite synapse) model based on leaky integrate fire neuron astrocyte-synapse models area-efficient hardware approach called stochastic computing paradigm. proposed synthesized physically field-programmable gate array proof concept. implementation results presented mimic bidirectional communication biological minimal network pre-postsynaptic Ca2+-based for astrocyte with considerably lower cost. influence astrocytes neural behavioral has been investigated providing proper mechanism considering gap junction coupling various coefficients desynchronizing impaired synchronization coupled neurons.